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Published on: December 11, 2016

Medication discrepancies and medication-related problems in psychiatric patients: A medication reconciliation study

Mozhdeh Shahabi1,2, Mahsa Panahishokouh3, Niayesh Mohebbi4

  • 1School of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
|May 15, 2026
PubMed
Abstract

Insights

Psychiatric patients frequently experience medication errors, including non-adherence and drug interactions. Medication reconciliation programs are crucial for identifying and resolving these medication-related problems in psychiatric care.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Patient Safety

Background:

  • Medication discrepancies (MDs) are common errors leading to adverse drug events.
  • Medication reconciliation (MR) programs aim to prevent MDs and medication-related problems (MRPs).
  • Psychiatric settings face unique challenges like polypharmacy and limited patient cooperation, increasing MRP risks.

Purpose of the Study:

  • To investigate the prevalence of MDs and MRPs in psychiatric patients.
  • To identify common MRPs in this population.
  • To underscore the importance of MR programs in psychiatric care.

Main Methods:

  • A study of 302 psychiatric patients on at least two daily systemic medications.
  • Medication review at discharge using Pharmaceutical Society of Australia (PSA) guidelines.
  • Statistical analysis of collected data.

Main Results:

  • Patients averaged 4.71 medications; 493 MDs and 392 MRPs were identified.
  • Most common MRPs: medication underuse/non-adherence (44.64%) and drug interactions (42.85%).
  • Drug interactions significantly increased with more diseases and medications (P < 0.001).

Conclusions:

  • High prevalence of MRPs in psychiatric settings necessitates robust MR programs.
  • Non-adherence and drug interactions are key challenges for psychiatric patients.
  • Effective MR programs are vital for mitigating risks and improving patient outcomes.
Keywords:
Medication discrepancyMedication reconciliationPsychiatric disorderPsychotropic medication

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