Related Experiment Videos

Assessment of triglyceride-glucose composite indices associated mortality risk in diabetes-related heart failure

Qijie Zhao1, Xiao Cai2, Xing Wang3

  • 1Department of Pharmacy, West China Hospital of Sichuan University, Chengdu, People's Republic of China.

Journal of Diabetes Investigation
|May 16, 2026
PubMed

Insights

The triglyceride-glucose (TyG) index, particularly TyG-Age, strongly predicts mortality in patients with diabetes-related heart failure (dHF). These indices, along with the TRS-HFDM score, can help identify high-risk dHF patients for better clinical management.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Diabetes mellitus significantly increases the risk of heart failure.
  • The triglyceride-glucose (TyG) index is a known risk factor for diabetes-related heart failure (dHF).
  • A validated clinical risk score is needed to identify dHF patients at high risk.

Purpose of the Study:

  • To validate a practical clinical risk score (TRS-HFDM) for dHF in a large diabetic cohort.
  • To assess if the TRS-HFDM score can identify dHF patients with elevated TyG index and poor outcomes.
  • To evaluate the prognostic value of TyG-related indices for mortality in dHF patients.

Main Methods:

  • Analysis of data from multiple NHANES cycles (1999-2018) involving 3,455 participants with dHF.
  • Calculation of a simplified TRS-HFDM score and TyG-related parameters.
  • Utilized multivariable Cox proportional hazards models, Kaplan-Meier curves, and restricted cubic splines (RCS) to identify independent predictors.

Main Results:

  • Higher TRS-HFDM scores were significantly associated with poorer survival in dHF patients.
  • High quartile levels of TyG-related indices, especially TyG-Age, were significantly associated with increased mortality (TyG-Age HR=6.94).
  • Nonlinear trends indicated a strong correlation between TyG-Age indices and dHF mortality.

Conclusions:

  • TyG-related indices, particularly TyG-Age, possess significant prognostic value for mortality in adults with dHF.
  • TyG-Age and TRS-HFDM can serve as valuable surrogate biomarkers for the clinical management of dHF.
  • These findings support the use of TyG-Age and TRS-HFDM in risk stratification for dHF patients.
Abstract

Keywords:
DiabetesHeart failureThrombolysis in Myocardial Infarction risk score for heart failure in diabetes (TRS‐HFDM)

Related Concept Videos

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...