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Updated: May 17, 2026

Epithelial Cell Infection Analyses with Shigella
Published on: February 9, 2024
A case of carbapenamase production in Shigella flexneri isolated in Ireland, 2025
Christina Clarke1, Alma Tuohy1, Erica Duignan2
1Galway Reference Laboratory Service, Galway University Hospital, Galway, Ireland.
Abstract:
Shigella flexneri producing OXA-181 was detected from a patient in Ireland in October 2025. The isolate had a meropenem minimum inhibitory concentration (MIC) of 0.12 mg/L. Carbapenemase production was detected by lateral flow immunoassay. The sequence type was ST245 and closely related to sequences previously reported from Ireland and other countries but not previously linked to presence of the bla OXA-181 gene. Carbapenemase production in Shigella spp. has implications for laboratory detection and empiric treatment.
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