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Further asterosaponins from the Vietnamese starfish Archaster typicus
Le Thi Vien1, Tran Thi Hong Hanh1, Ninh Thi Ngoc1
1Department of Marine Medicinal Materials, Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Vietnam.
Abstract:
Using combined chromatographic separations, seven asterosaponins, including two new ones archasterosides D and E (1 and 2), were isolated from the methanol extract of the starfish Archaster typicus. Their chemical structures were characterized by extensive analysis of the 1D, 2D NMR, and HR QTOF mass spectra. Among isolated compounds, asteropiside A (3) revealed significant cytotoxic effect against all the five cell lines SK-LU-1 (lung carcinoma), HepG2 (hepatocarcinoma), MCF7 (breast carcinoma), LNCaP (prostate carcinoma), and KB (carcinoma in the mouth) with IC50 values ranging from 9.80 ± 0.58 to 13.88 ± 1.01 µM.
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