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Related Experiment Video

Updated: May 18, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Dietary Procyanidin C1 Improves Cognitive Function through MicroRNA-181a-5p.

Kwanwoo Lee1, Saki Umemoto1, Jaehoon Bae1,2

  • 1Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.

Journal of Agricultural and Food Chemistry
|May 16, 2026
PubMed
Summary

Procyanidin C1 (PC1) enhances cognitive function by increasing microRNA-181a-5p levels. This dietary polyphenol impacts neural pathways, offering insights into brain health and polyphenol absorption mechanisms.

Keywords:
(−)-epicatechin trimmer67-kDa laminin receptorand BDNFcognitive functionmiR-181a-5pp-CREBp-ERKprocyanidin C1

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Last Updated: May 18, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Nutritional Science

Background:

  • Procyanidin C1 (PC1), a polyphenol from cocoa, grapes, and apples, has known health benefits but low absorption and unknown mechanisms.
  • Understanding how dietary compounds like PC1 affect neural function is crucial for developing effective health strategies.

Purpose of the Study:

  • To elucidate the molecular mechanisms by which Procyanidin C1 (PC1) influences neural function and cognitive abilities.
  • To identify key regulators involved in PC1's biological effects, particularly concerning brain health.

Main Methods:

  • Investigated the effect of PC1 on spatial working memory and cognitive ability in vivo.
  • Analyzed the role of circulating microRNA (miR)-181a-5p as a mediator of PC1's effects.
  • Examined the involvement of the 67-kDa laminin receptor (67LR) in PC1-induced signaling.
  • Assessed changes in brain-derived neurotrophic factor (BDNF), CREB, and ERK phosphorylation in the hippocampus.

Main Results:

  • PC1 administration improved spatial working memory and cognitive ability.
  • PC1 upregulated circulating miR-181a-5p via the 67LR pathway.
  • Upregulation of miR-181a-5p by PC1 modulated BDNF and its downstream signaling.
  • Inhibition of miR-181a-5p reversed PC1-induced cognitive improvements and molecular changes in the hippocampus.

Conclusions:

  • PC1 enhances cognitive function through a mechanism involving the upregulation of miR-181a-5p via the 67LR.
  • This pathway modulates BDNF signaling, impacting neural plasticity and cognitive regulation.
  • The study reveals a novel gut-PC1-miRNA-67LR-BDNF axis influencing brain function, offering insights into poorly absorbed polyphenol efficacy.