Dual-trajectories of Systolic Blood Pressure and Modified Life's Essential 8 With Gastrointestinal Cancer and...

This study aimed to describe joint longitudinal patterns of SBP and modified Life's Essential 8 (LE8) and to further investigate their associations with risks of gastrointestinal cancer and all-cause mortality in the Kailuan Study. Since systolic blood pressure (SBP) was used to assess the dual-trajectories, modified LE8 score was calculated as the average of 7 component score after excluding blood pressure. A group-based dual-trajectories model was used to characterize joint longitudinal patterns of SBP and modified LE8 using data from 2006/2007 to 2014/2015 survey. Multivariable Cox proportional hazards regression models were used to assess associations of dual-trajectories patterns with risks of gastrointestinal cancer and all-cause mortality (hazard ratio, HR and 95% confidence interval, 95% CI). A total of 48,596 participants were included in the current analysis, and five dual-trajectories groups were identified. Compared with group 3, group 2 had the highest risk of gastrointestinal cancer (HR, 1.64; 95% CI, 1.17-2.29), followed by group 4 and group 5, whereas group 1 had the lowest risk of gastrointestinal cancer (HR, 1.09; 95% CI, 0.78-1.51). Similar results were observed for associations between dual-trajectories of SBP and modified LE8 and all-cause mortality. This study found joint longitudinal patterns of SBP and modified LE8 and revealed their associations with the risks of gastrointestinal cancer and all-cause mortality. The findings suggest that individuals with lower modified LE8 scores had higher risks of gastrointestinal cancer and all-cause mortality even at similar SBP levels, underscoring the importance of comprehensive cardiovascular health for risk stratification and prevention.