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Mesoporous polydopamine-based biomimetic nanodelivery systems: recent advances in precision therapy
Chao Tao1, Shangshu Lu1, Ke Wang1
1Department of Pharmacy, the Affiliated Hospital, Southwest Medical University, Luzhou, China; Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, China.
International Journal of Pharmaceutics
|May 16, 2026
Summary
Mesoporous polydopamine (MPDA) nanoparticles offer great potential for drug delivery due to their unique properties. Biomimetic modifications enhance their stability and targeting, improving therapeutic outcomes for various diseases.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Mesoporous polydopamine (MPDA) possesses advantageous properties like high surface area and photothermal efficiency for drug delivery.
- Unmodified MPDA faces challenges in vivo, including rapid immune clearance and lack of active targeting.
Purpose of the Study:
- To review the structural design, biological functions, and progress of MPDA-based biomimetic nanodelivery systems.
- To highlight the therapeutic applications and multimodal strategies enabled by these advanced nanocarriers.
Main Methods:
- Systematic review of literature on MPDA nanodelivery systems.
- Analysis of biomimetic modification strategies, focusing on biological membrane coatings.
- Evaluation of applications in various disease models and therapeutic modalities.
Main Results:
- Biomimetic modifications, such as membrane coating, significantly improve MPDA circulation time, immune evasion, and targeting.
- MPDA-mediated systems demonstrate efficacy in treating tumors, inflammation, wound healing, fibrosis, and atherosclerosis.
- Multimodal therapeutic approaches (chemotherapy, PTT, PTT, PDT, etc.) are effectively integrated.
Conclusions:
- MPDA-based biomimetic nanodelivery systems show great promise for precision medicine.
- Advancements in biomimetic engineering and imaging will further expand their therapeutic potential.
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