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The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
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Aberrant increased GABAergic neuronal activity in postrhinal cortex impairs spatial memory.

Jihong Zhang1, Mengyu Liu2, Duohao Wang1

  • 1Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

Behavioural Brain Research
|May 16, 2026
PubMed
Summary

Hyperactivity of postrhinal cortex (POR) GABAergic neurons impairs spatial memory in rodents by suppressing neuronal activity. This finding clarifies the role of these neurons in spatial memory and disease research.

Keywords:
GABAergic neuronsParahippocampal cortexPostrhinal cortexSpatial memory

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Memory Research

Background:

  • The postrhinal cortex (POR) is crucial for spatial and object recognition memory.
  • POR glutamatergic neurons regulate spatial memory retrieval.
  • The function of POR GABAergic neurons in memory remains unclear.

Purpose of the Study:

  • To investigate the role of POR GABAergic neurons in spatial and object recognition memory.
  • To elucidate the mechanism by which POR GABAergic neurons influence memory functions.

Main Methods:

  • Confirmation of GABAergic neuron presence in the POR.
  • Experimental manipulation of POR GABAergic neuron activity (hyperactivity).
  • Assessment of spatial and object recognition memory performance.

Main Results:

  • POR contains a significant population of GABAergic neurons.
  • Hyperactivity of POR GABAergic neurons impairs spatial memory.
  • Object recognition memory remains unaffected by POR GABAergic neuron hyperactivity.
  • Hyperactivity may impair spatial memory by suppressing surrounding neuronal activity.

Conclusions:

  • POR GABAergic neurons play a specific role in spatial memory.
  • Dysfunction of POR GABAergic neurons can lead to spatial memory deficits.
  • Findings offer insights into spatial memory decline and related diseases.