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Related Concept Videos

Penis01:29

Penis

The penis serves a dual role in sexual reproduction and urination. It consists of three main regions: the glans penis, the body, and the root, each with distinct functions and unique anatomical features.
Anatomy of the Penis
The glans penis, or the head, is the terminal part of the penis and houses the external urethral orifice, the exit point for urine and semen. Covered by the prepuce, or foreskin, the glans is noted for its sensitivity and plays a key role in sexual pleasure. The body of the...
Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...

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Related Experiment Video

Updated: May 18, 2026

Microscopic Replantation of Penile Glans Amputation Due to Circumcision
07:28

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Published on: June 3, 2022

Pathologic Differences in Adult Acquired Buried Penis Patients by Exhumable Status.

Andrea Quinn1, Parker Holum1, William Daly1

  • 1UPMC Department of Urology, Pittsburgh, PA.

Urology
|May 16, 2026
PubMed
Summary

Patients with adult acquired buried penis disease whose penises cannot be fully examined preoperatively have a higher risk of premalignant skin conditions. Upfront surgical correction is recommended due to diagnostic uncertainty and potential adverse pathology.

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Area of Science:

  • Urology
  • Dermatopathology
  • Surgical Oncology

Background:

  • Adult acquired buried penis disease presents diagnostic challenges when full preoperative examination is not feasible.
  • Limited examination increases the risk of overlooking significant penile pathologies.

Purpose of the Study:

  • To compare the incidence of penile cancer and urethral stricture disease in patients with adult acquired buried penis disease based on preoperative penile exposure.
  • To assess the risk of premalignant conditions in cases where the penis cannot be fully examined.

Main Methods:

  • A retrospective cohort review of 203 patients undergoing adult acquired buried penis repair.
  • Preoperative penile exposure was assessed via medical records and operative reports.
  • Pathological analysis by a genitourinary pathologist identified lichen sclerosus and penile cancer.

Main Results:

  • Patients with unexposed penises had a significantly higher likelihood of lichen sclerosus (28.4% vs 13.8%).
  • No significant difference was found in the risk of penile cancer (6.5% vs 2.5%) or urethral stricture disease (26.3% vs 35.0%).

Conclusions:

  • Incomplete preoperative examination of the penis in adult acquired buried penis disease is associated with an increased risk of premalignant conditions.
  • Clinicians must communicate diagnostic uncertainty and heightened risks to patients.
  • Upfront surgical intervention is strongly advised for patients with limited preoperative examination due to associated risks.