Back to the future! Is there still a role for the GnRH agonist protocol in ovarian stimulation?

For more than two decades, gonadotrophin-releasing hormone (GnRH) agonist protocols were used as the standard stimulation regimen in IVF, due to the effective prevention of premature LH surges and reduced cycle cancellation rates. Over the past two decades, however, their use has markedly declined with the widespread adoption of GnRH antagonist and progestin-primed ovarian stimulation protocols, which offer shorter treatment durations and greater patient convenience. This article examines the contemporary evidence on GnRH agonist protocols and identifies patient subgroups in whom their use may remain clinically relevant.