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Updated: May 19, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
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Published on: March 8, 2017

Hyperacusis-inducing drug candidates.

Richard Salvi1, Tang-Chuan Wang2, Ann Eddins1

  • 1Communication Sciences and Disorders, University of Central Florida, Orlando, FL 32826-3246, USA.

Hearing Research
|May 17, 2026
PubMed
Summary
This summary is machine-generated.

Drug-induced hyperacusis, a hypersensitivity to sound, is linked to various medications. This analysis of adverse event reports identified 10 drug classes potentially causing this condition, aiding future research.

Keywords:
AnticonvulsantsBenzodiazepinesFluoroquinolone antibioticsHyperacusisSelective serotonin reuptake inhibitorsSelective serotonin-norepinephrine reuptake inhibitors

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09:18

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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

Area of Science:

  • Pharmacovigilance
  • Neuroscience
  • Otolaryngology

Background:

  • Hyperacusis, characterized by loudness hypersensitivity and potential pain, has poorly understood neural origins.
  • Identifying triggers for hyperacusis is crucial for understanding and managing the condition.

Purpose of the Study:

  • To investigate potential drug-induced causes of hyperacusis through pharmacovigilance analysis.
  • To identify drug classes associated with reported hyperacusis adverse events.

Main Methods:

  • Analysis of 3833 case reports from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS).
  • Focus on cases where hyperacusis was listed as a drug-induced adverse event.
  • Ranking of drug classes by the number of reported hyperacusis cases.

Main Results:

  • Selective serotonin reuptake inhibitors, fluoroquinolone antibiotics, and serotonin-norepinephrine reuptake inhibitors were among the top drug classes associated with hyperacusis.
  • Approximately 70% of reported cases involved females, potentially due to reporting bias.
  • Common comorbidities included headache, photophobia, nausea, fatigue, dizziness, anxiety, insomnia, tinnitus, and depression.

Conclusions:

  • This study provides a foundation for further research into drug-induced hyperacusis.
  • Future studies, including animal models, are needed to determine dose-dependent effects of implicated drugs.