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Updated: May 19, 2026
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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Published on: May 20, 2016
Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies-A Systematic
Jeniffer Viviana Ramirez Hernández1, Sara Elis Bianchi1, Flávia Nathiely Silveira Fachel1
1Programa de Pós-Graduação Em Ciências Farmacêuticas, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
Phytotherapy Research : PTR
|May 17, 2026
Summary
Flavonoids, natural compounds with health benefits, can be delivered via the nose. This nasal route offers topical effects, treats respiratory issues, and enables targeted brain delivery for CNS diseases.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Drug Delivery Systems
Background:
- Flavonoids are key secondary metabolites with diverse biological activities and health applications.
- Oral administration of flavonoids as heterosides is common, but alternative routes offer new therapeutic potential.
- Nasal administration of flavonoids (aglycones) presents a novel strategy for local, systemic, or targeted delivery.
Purpose of the Study:
- To systematically review flavonoid classes and administration routes.
- To explore the therapeutic potential of nasal flavonoid administration.
- To emphasize flavonoid roles at three levels of nasal delivery: topical, systemic, and nose-to-brain.
Main Methods:
- Systematic literature search following PRISMA guidelines.
- Databases searched: Web of Science and PubMed (December 1997-November 2024).
- Inclusion criteria applied to 225 retrieved records, with 40 studies meeting criteria.
Main Results:
- Nasal administration allows for topical effects on nasal mucosal epithelia.
- Flavonoids administered nasally can treat naso-respiratory and other diseases.
- The nose-to-brain pathway facilitates targeted flavonoid delivery for central nervous system (CNS) diseases.
Conclusions:
- Nasal flavonoid administration is a promising therapeutic strategy.
- This route offers versatile applications from local treatment to targeted brain delivery.
- Further research into nasal flavonoid delivery could unlock new treatments for various health conditions, including CNS disorders.
- Meta_A_Description
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