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Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...

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Updated: May 19, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Multiparametric MR Imaging for Evaluating Renal Function and Microstructure.

Akira Yamamoto1, Yu Ueda2, Hideki Kagioka1

  • 1Department of Radiology, Kawasaki Medical School, Kurashiki Okayama, Japan.

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
|May 17, 2026
PubMed
Summary
This summary is machine-generated.

Functional renal MRI offers a noninvasive way to assess chronic kidney disease (CKD) and diabetic kidney disease (DKD). Multiparametric MRI techniques show promise for evaluating kidney microstructure and predicting disease progression, complementing traditional biomarkers.

Keywords:
chronic kidney diseaseclinical applicationfunctional magnetic resonance imagingmagnetic resonance imagingrenal function

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Area of Science:

  • Nephrology
  • Radiology
  • Biomedical Engineering

Background:

  • Chronic kidney disease (CKD) is a significant global health issue with diverse causes.
  • Current biomarkers like serum creatinine and eGFR may not detect early CKD or correlate with structural damage.
  • Diabetic kidney disease (DKD) presents complex pathophysiology that challenges conventional assessment.

Purpose of the Study:

  • To provide a comprehensive review of multiparametric MRI techniques for evaluating renal microstructure and physiology in CKD.
  • To highlight the potential of functional renal MRI as a noninvasive tool for assessing kidney health.
  • To discuss the role of MRI in risk stratification and understanding DKD.

Main Methods:

  • Overview of various MRI techniques: T1/T2 mapping, BOLD MRI, diffusion-based methods (ADC, DTI, IVIM), and arterial spin labeling.
  • Focus on multiparametric approaches and integrative features like corticomedullary differentiation (CMD).
  • Discussion of noncontrast SSFP with multi-TI for CMD assessment.

Main Results:

  • Many MRI-derived metrics correlate with kidney function (eGFR).
  • Diffusion indices, especially cortical ADC, show potential for predicting subsequent eGFR decline.
  • Multiparametric MRI may offer added value in complex cases like DKD.

Conclusions:

  • Functional renal MRI is a promising noninvasive method for assessing CKD and DKD.
  • MRI-derived metrics, particularly diffusion indices, may aid in progression-risk assessment.
  • Standardization, quality control, and multicenter validation are crucial for clinical translation.