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Recurrent Focal-type Takotsubo Syndrome Following Prior Mid-ventricular Variant.

Takeshi Ishihara1, Hiroyuki Okura1

  • 1Department of Cardiology, Gifu University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|May 17, 2026
PubMed
Summary
This summary is machine-generated.

This case study details an extremely rare instance of recurrent Takotsubo syndrome (TTS) with a changing subtype. It underscores the diagnostic difficulties and imaging needs for focal-type TTS.

Keywords:
Takotsubo syndromefocal-typeleft ventriculography

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Area of Science:

  • Cardiology
  • Cardiac Imaging
  • Medical Case Reports

Background:

  • Takotsubo syndrome (TTS) is a transient cardiac dysfunction mimicking acute coronary syndrome.
  • Recurrence of TTS is uncommon, and changes in morphological subtype are particularly rare.
  • Focal-type TTS presents unique diagnostic challenges.

Purpose of the Study:

  • To report an extremely rare case of recurrent Takotsubo syndrome with a change in morphological subtype.
  • To highlight the diagnostic challenges associated with focal-type TTS.
  • To emphasize the importance of specific imaging modalities in diagnosing recurrent and atypical TTS.

Main Methods:

  • Case report of an 83-year-old woman with recurrent Takotsubo syndrome.
  • Initial diagnosis and subsequent recurrence assessment.
  • Echocardiography and left ventriculography utilized for diagnosis.

Main Results:

  • The patient initially presented with mid-ventricular type TTS and later developed focal-type TTS.
  • Echocardiography findings were inconclusive for the second episode.
  • Left ventriculography confirmed the diagnosis of focal-type TTS.

Conclusions:

  • This case represents an exceptionally rare occurrence of recurrent Takotsubo syndrome with a shift in morphological subtype.
  • Focal-type TTS diagnosis can be challenging, especially with inconclusive non-invasive imaging.
  • Left ventriculography is crucial for definitive diagnosis in suspected recurrent TTS with atypical presentations.