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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...

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Updated: May 19, 2026

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
07:45

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and

Marie Frutoso1, Emie Delmas1, Rudolf Corty1

  • 1LBAI, UMR1227, Univ Brest, Inserm, Brest, France.

Immunological Reviews
|May 18, 2026
PubMed
Summary
This summary is machine-generated.

Lymphoid structures (LS) in nonlymphoid tissues are diverse immune niches. This review distinguishes inflammatory LS (ILS) from mature tertiary LS (mTLS), impacting autoimmunity, cancer, and aging.

Keywords:
B cellsautoimmunitycell lineages and subsetsimmune‐mediated diseasesinflammationprocesses

Related Experiment Videos

Last Updated: May 19, 2026

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
07:45

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

Area of Science:

  • Immunology
  • Pathology
  • Tissue Engineering

Background:

  • Lymphoid structures (LS) in nonlymphoid tissues are increasingly viewed as dynamic immune niches, not just inflammatory byproducts.
  • A proposed framework differentiates inflammatory LS (ILS) from mature tertiary LS (mTLS), recognizing a potential continuum and distinct inflammatory states.

Purpose of the Study:

  • To present a framework for classifying LS in nonlymphoid tissues.
  • To explore the development and functional impact of LS across various conditions.
  • To discuss therapeutic strategies and advanced detection methods for LS.

Main Methods:

  • Review of existing literature on LS development and function.
  • Comparative analysis of ILS and mTLS characteristics.
  • Discussion of emerging technologies like spatial transcriptomics and AI.

Main Results:

  • LS development is influenced by autoimmunity, cancer, transplantation, immune-related adverse events, and aging.
  • mTLS exhibit follicular organization and germinal center reactions, while ILS involve extrafollicular activation and immune specialization.
  • The function of LS is context-dependent, ranging from promoting autoimmunity to supporting anti-tumor immunity or immune suppression.

Conclusions:

  • LS represent heterogeneous tissue immune niches, not a single category.
  • Understanding LS heterogeneity is crucial for pathogenesis, biomarker discovery, and therapeutic interventions.
  • Advanced techniques will refine LS detection, classification, and functional interpretation.