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Updated: May 19, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

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Published on: September 15, 2017

Association Between Serum Cortisol Levels and Variant Angina.

Jeen Hwa Lee1, Sung Rok Lee2, Yeon Jung Lee1

  • 1Division of Cardiology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

Korean Circulation Journal
|May 18, 2026
PubMed
Summary
This summary is machine-generated.

Elevated cortisol levels, a stress hormone, are associated with variant angina (VA), a condition caused by coronary vasospasm. This study found higher cortisol in VA patients, suggesting a link between stress and vasospasm.

Keywords:
BiomarkerCoronary vasospasmHydrocortisoneStress, psychological

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Published on: August 23, 2019

Area of Science:

  • Cardiology
  • Endocrinology
  • Psychosomatic Medicine

Background:

  • Variant angina (VA) involves coronary vasospasm, potentially triggered by psychological stress.
  • The relationship between cortisol, a stress hormone, and VA is not well-established.
  • Understanding this link may offer new insights into VA pathophysiology.

Purpose of the Study:

  • To investigate the association between serum cortisol levels and variant angina.
  • To determine if cortisol is an independent predictor of VA.

Main Methods:

  • Prospective study of 192 patients undergoing coronary angiography.
  • Serum cortisol, norepinephrine, and ACTH measured at admission and post-angiography.
  • Multivariable logistic regression used to identify factors associated with VA.

Main Results:

  • 23% of patients were diagnosed with VA.
  • VA patients had significantly higher cortisol levels at admission and on day 1 compared to controls.
  • Higher admission cortisol was independently associated with VA, along with younger age and lower CRP.

Conclusions:

  • Variant angina patients exhibit elevated cortisol during the acute phase.
  • These findings suggest a link between stress-induced cortisol elevation and coronary vasospasm.
  • Further clinical research is warranted to explore this association.