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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Two Unpresented Triterpenoid Saponins From Dipsacus asper.
Ling Xu1,2, Wen-Yan Li2, Zhi-Ping Zhou2
1School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China.
Chemistry & Biodiversity
|May 18, 2026
Summary
Two new triterpenoid saponins, dipersaponin A and B, were isolated from Dipsacus asper. Dپرسaponin B showed activity in inhibiting acid-sensing ion channel 1a (ASIC1a).
Area of Science:
- Natural Products Chemistry
- Pharmacology
Background:
- Dipsacus asper is a plant source of bioactive compounds.
- Triterpenoid saponins are a class of natural products with diverse biological activities.
- Acid-sensing ion channels (ASICs) are involved in various physiological processes and diseases.
Purpose of the Study:
- To isolate and characterize novel triterpenoid saponins from Dipsacus asper.
- To evaluate the ASIC1a channel inhibitory activity of the isolated compounds.
Main Methods:
- Phytochemical investigation of Dipsacus asper methanolic extract.
- Structure elucidation using spectroscopic techniques (IR, UV, MS, 1D/2D NMR) and ECD calculations.
- In vitro assay for ASIC1a channel inhibition.
Main Results:
- Two new triterpenoid saponins, dipersaponin A (1) and dipersaponin B (2), were identified.
- Three known analogs (3-5) were also isolated and characterized.
- Dipersaponin B (2) demonstrated inhibitory activity against ASIC1a with an IC50 value of 41.99 ± 0.95 µM.
Conclusions:
- Dipersaponin A and B are novel triterpenoid saponins from Dipsacus asper.
- Dipersaponin B possesses significant ASIC1a inhibitory potential, suggesting its therapeutic relevance.
