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Related Concept Videos

Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a program...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...

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Related Experiment Video

Updated: May 19, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

The gut-brain axis: a two-way relationship.

Katherine Clarke, Sarah Heath

    The Veterinary Record
    |May 18, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Veterinary specialists Katherine Clarke and Sarah Heath will explore the brain-gut connection in animals. Their discussion will cover how the brain and gut influence each other, impacting animal health and behavior.

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    Last Updated: May 19, 2026

    A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
    09:18

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    Published on: July 28, 2023

    Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
    07:29

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    Published on: December 29, 2023

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    07:49

    Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

    Published on: June 2, 2022

    Area of Science:

    • Veterinary medicine
    • Neuroscience
    • Gastroenterology

    Background:

    • The gut-brain axis is a complex bidirectional communication system.
    • Understanding this axis is crucial for diagnosing and treating various animal conditions.
    • Veterinary internal medicine and behavioral medicine often encounter manifestations of gut-brain axis dysregulation.

    Purpose of the Study:

    • To explore the intricate relationship between the brain and the gut in veterinary medicine.
    • To discuss the impact of the gut-brain axis on animal health and behavior.
    • To highlight the interdisciplinary approach needed to address conditions related to this axis.

    Main Methods:

    • Expert discussion and case study review.
    • Integration of knowledge from veterinary internal medicine and veterinary behavioral medicine.
    • Focus on the physiological and psychological aspects of the gut-brain axis.

    Main Results:

    • The brain significantly influences gut function through neural, endocrine, and immune pathways.
    • Gut microbiota and inflammation can profoundly affect brain function, mood, and behavior.
    • Dysregulation of the gut-brain axis contributes to a range of clinical signs in animals.

    Conclusions:

    • A holistic understanding of the gut-brain axis is essential for effective veterinary care.
    • Collaboration between specialists in internal medicine and behavioral medicine can improve patient outcomes.
    • Further research into the gut-brain axis will unlock new diagnostic and therapeutic strategies for animals.