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Updated: May 19, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
[Cutaneous squamous cell carcinoma, what you should know in 2026]
Michaël Ghose1, Edouard Romano2, Jöri Puenchera3
1Service d'oncologie, Département d'oncologie, Hôpitaux universitaires de Genève, 1211 Genève 14.
None:
Cutaneous squamous cell carcinoma (cSCC) is a common cancer with a rising incidence, mainly due to cumulative ultraviolet exposure and immunosuppression. Surgery remains the standard treatment for localized disease, most often providing sustained tumor control. Radiotherapy is an alternative or adjunct option, particularly in cases of surgical contraindications or high-risk features after resection, and can be used as a definitive treatment in some elderly or comorbid patients. Immunotherapy with checkpoint inhibitors has transformed the management of advanced cSCC, inducing high and long-lasting response rates. Promising results in the neoadjuvant and adjuvant settings are paving the way for multimodal strategies and a potential de-escalation of locoregional treatments.
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