Nanofibrous Platforms for Advanced Wound Therapeutics: Mechanisms, Materials, and Clinical Horizons

Nanofibrous dressings have emerged as a transformative solution for acute and chronic wound management. This review evaluates recent advancements in wound therapeutics utilizing nanofiber platforms incorporating various bioactive agents. A comprehensive overview of the wound healing process across distinct physiological phases is provided, alongside a discussion of nanofiber fabrication methodologies and their underlying mechanisms. Particular emphasis is placed on the constituent materials and their inherent biofunctionality, specifically regarding how cellular interactions with these substrates enhance wound healing outcomes. Furthermore, we examine the clinical utility of these scaffolds in achieving hemostasis, modulating inflammation, preventing infection, and promoting angiogenesis. The review concludes by highlighting the cost-effectiveness and tunable architecture of nanofibers, underscoring their potential as the next generation of efficacious wound care systems.