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Exploring the Role of the MAPK Signalling Pathway in Dog Immunity: From Cancer to Parasitic Diseases

Francini Neves Ribeiro1,2, Fernanda Nazaré Morgado2,3, Renato Porrozzi1

  • 1Laboratório de Protozoologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.

Parasite Immunology
|May 18, 2026
PubMed

Insights

Mitogen-activated protein kinases (MAPKs) are crucial signaling proteins. This review explores their role in canine immune, inflammatory, and parasitic diseases, highlighting potential therapeutic targets.

Area of Science:

  • Veterinary Medicine
  • Immunology
  • Molecular Biology

Background:

  • Mitogen-activated protein kinases (MAPKs) are intracellular signaling proteins regulating cellular processes like proliferation and survival.
  • MAPK pathway alterations are implicated in canine cancers and human diseases, including inflammatory and parasitic infections.
  • The role of MAPK signaling in canine parasitic diseases remains underexplored, despite parasites targeting these pathways for immune evasion.

Purpose of the Study:

  • To review the involvement of the MAPK pathway in the canine immune system.
  • To discuss the role of MAPKs in canine inflammatory diseases.
  • To explore the significance of the MAPK pathway in canine parasitic diseases.

Main Methods:

  • Literature review of existing studies on MAPK signaling in canine and human models.
  • Analysis of shared immune evasion mechanisms between parasites and cancer cells.
  • Synthesis of information on MAPK pathway involvement in disease pathogenesis.

Main Results:

  • MAPK signaling is altered in various canine pathological conditions, including cancer.
  • Parasites strategically target MAPK pathways to modulate host immune responses and ensure survival.
  • Immune evasion strategies employed by parasites share similarities with those of cancer cells.

Conclusions:

  • The MAPK pathway plays a significant role in canine immune responses, inflammation, and parasitic infections.
  • Understanding MAPK signaling in canine parasitic diseases is crucial for developing novel therapeutic strategies.
  • Further research into canine MAPK pathways could reveal shared mechanisms with cancer and other diseases.
Keywords:
MAPK pathwaycancercell signallingdogsimmune systemparasite survivalparasitic disease

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