Prevalence of orthokeratinized odontogenic cyst: A retrospective clinicopathological study

Orthokeratinized odontogenic cyst is a distinct developmental jaw cyst commonly misinterpreted at the clinical and radiographic level due to overlap with other keratinizing and tooth-associated cysts. Hence, 1,200 biopsy specimens were analyzed, identifying 30 histologically confirmed OOC cases. OOC constituted 10.0% of all odontogenic cysts and 2.5% of the total biopsy cohort. The majority of lesions affected males between 21-30 years and were predominantly located in the posterior mandible, frequently involving impacted teeth, especially the mandibular third molar. The study highlights its rarity, limited tissue aggression and the importance of microscopic confirmation for accurate diagnosis and appropriate treatment planning.