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CRP and IL-6 as cardiovascular risk markers in diabetes

Najmush Sahar Khan1, Ravi Ramkishan Yadav2, Shweta Kumari3

  • 1Department of Physiology, Santosh Deemed to be University, Ghaziabad, Delhi NCR, India.

Bioinformation
|May 18, 2026
PubMed

Insights

Inflammation markers, C-reactive protein (CRP) and Interleukin-6 (IL-6), predict cardiovascular risk in diabetic patients. Elevated CRP and IL-6 levels are linked to higher cardiovascular risk, aiding early intervention for diabetes complications.

Area of Science:

  • Biomarkers and Cardiovascular Health
  • Diabetes Mellitus Research
  • Inflammation and Disease

Background:

  • Cardiovascular diseases (CVD) are a primary cause of death in diabetic patients.
  • Identifying predictive biomarkers for cardiovascular risk is crucial for timely intervention.
  • Inflammatory markers are increasingly recognized for their role in CVD pathogenesis.

Purpose of the Study:

  • To investigate the predictive value of C-reactive protein (CRP) and Interleukin-6 (IL-6) for cardiovascular risk in patients with diabetes mellitus.
  • To assess the association between elevated CRP and IL-6 levels and cardiovascular risk stratification.
  • To determine if inflammation markers can identify diabetic individuals at higher risk for cardiovascular events.

Main Methods:

  • Analysis of C-reactive protein (CRP) and Interleukin-6 (IL-6) levels in diabetic patients.
  • Utilizing the Framingham Risk Score to assess cardiovascular risk.
  • Statistical analysis to determine the association between inflammatory markers and cardiovascular risk.

Main Results:

  • Elevated levels of both CRP and IL-6 were significantly associated with increased cardiovascular risk.
  • The Framingham Risk Score indicated higher cardiovascular risk in patients with elevated inflammatory markers.
  • CRP and IL-6 demonstrated potential as biomarkers for identifying high-risk diabetic individuals.

Conclusions:

  • Inflammation, as indicated by CRP and IL-6 levels, is a significant predictor of cardiovascular events in diabetic patients.
  • CRP and IL-6 can serve as valuable biomarkers for early identification of cardiovascular risk in diabetes.
  • This study reinforces the importance of monitoring inflammatory markers for cardiovascular risk management in diabetes mellitus.

Keywords:
C-reactive protein (CRP)cardiovascular riskdiabetesinflammationinterleukin-6 (IL-6)

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