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Published on: January 19, 2024

Impact of injectable vitamin B12 among malnourished Indian children

Shubham Saniyar1, Asmita Chakraborty1, Pushkar Singh Parihar1

  • 1Department of Pediatrics, Shyam Shah Medical College Rewa, Madhya Pradesh, India.

Bioinformation
|May 18, 2026
PubMed

Insights

Injectable vitamin B12 supplementation improved clinical and neurodevelopmental outcomes in young children with Severe Acute Malnutrition (SAM) and vitamin B12 deficiency. This intervention is vital for addressing deficiencies and supporting healthy development in vulnerable children.

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Public Health

Background:

  • Severe Acute Malnutrition (SAM) is frequently linked to micronutrient deficiencies, notably vitamin B12.
  • Vitamin B12 is essential for proper hematological function and neurodevelopment in early childhood.
  • Deficiency can lead to severe clinical illness, developmental delays, and regression of milestones.

Purpose of the Study:

  • To evaluate the impact of injectable vitamin B12 supplementation.
  • To assess clinical and neurodevelopmental outcomes in SAM children with vitamin B12 deficiency.
  • To understand vitamin B12's role in improving outcomes for SAM children.

Main Methods:

  • A study involving children aged 6-30 months with SAM and vitamin B12 deficiency.
  • Utilized clinical, neurological, and neurodevelopmental assessments.
  • Intervention involved three months of injectable vitamin B12 supplementation.

Main Results:

  • Significant improvements observed in clinical status post-supplementation.
  • Positive impacts on neurodevelopmental assessments were noted.
  • Vitamin B12 supplementation effectively addressed deficiency-related issues.

Conclusions:

  • Injectable vitamin B12 is effective in improving clinical and neurodevelopmental outcomes in SAM children.
  • Supplementation plays a crucial role in mitigating the adverse effects of vitamin B12 deficiency in this population.
  • This intervention strategy supports comprehensive recovery and development in malnourished children.

Keywords:
Severe acute malnutrition (SAM)injectable vitamin B12neurodevelopmental delayvitamin B12 deficiency

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