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Related Experiment Videos

Nickel sensitivity in the general population.

L Peltonen

    Contact Dermatitis
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Nickel sensitivity affects 4.5% of the population over 10, with higher rates in females. Most sensitive individuals had prior dermatitis, and 1.6% showed active eczema during testing.

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    Area of Science:

    • Dermatology
    • Allergology
    • Epidemiology

    Background:

    • Nickel allergy is a common contact allergen.
    • Prevalence and clinical manifestations require population-based data.

    Purpose of the Study:

    • To determine the incidence of nickel sensitivity in a general population.
    • To investigate the association between nickel sensitivity and dermatitis, particularly hand eczema.

    Main Methods:

    • Epicutaneous testing with 5% nickel sulfate was conducted on 980 individuals aged 10+.
    • Participants included school, occupational, and elderly subjects.
    • Data on history of dermatitis and presence of eczema were collected.

    Main Results:

    • Nickel sensitivity was found in 4.5% of the population (8% of females, 0.8% of males).

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  • 42 out of 44 nickel-sensitive subjects reported a history of metal contact dermatitis.
  • Manifest nickel sensitivity with active eczema was observed in 1.6% of all subjects (2.8% of females, 0.4% of males).
  • Nickel sensitivity and hand eczema co-occurred in 0.9% of the population.

    • Conclusions:

    • Nickel sensitivity is prevalent in the general population, particularly in females.
    • A history of dermatitis is strongly associated with nickel sensitivity.
    • Nickel sensitivity is a significant factor in hand eczema, though less frequently occupationally related.