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Related Concept Videos

Modeling in Therapy01:26

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Autism Spectrum Disorder01:19

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Related Experiment Video

Updated: May 19, 2026

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

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Published on: April 22, 2015

Development and Pilot Testing of Transdiagnostic Exposure Therapy/Behavioral Activation for Autistic Adolescents With

Andrew G Guzick1, Elizabeth A Kaplan-Kahn2, Jessica Szu-Chi Cheng3

  • 1University of Pennsylvania.

Cognitive and Behavioral Practice
|May 18, 2026
PubMed
Summary

A new transdiagnostic exposure therapy/behavioral activation intervention shows promise for autistic adolescents with internalizing disorders. Pilot testing revealed high feasibility, acceptability, and a significant treatment response rate, justifying further research.

Keywords:
anxietyanxiety disorderautism spectrum disorderdepressionmajor depressive disordertherapytreatment

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Published on: September 12, 2011

Area of Science:

  • Psychiatry
  • Developmental Psychology
  • Clinical Psychology

Background:

  • Internalizing disorders are prevalent in autistic adolescents, yet tailored therapeutic interventions remain scarce.
  • Existing research on therapy for this population is limited, highlighting a critical need for specialized approaches.

Purpose of the Study:

  • To develop a transdiagnostic exposure therapy/behavioral activation intervention for autistic adolescents with internalizing disorders.
  • To pilot test the feasibility, acceptability, and preliminary efficacy of this novel intervention.

Main Methods:

  • The intervention was developed by adapting existing exposure-based cognitive behavioral therapy, incorporating autism-specific considerations, caregiver involvement, and a neurodiversity-affirming lens.
  • A pilot study involved 14 adolescent-caregiver dyads, assessing feasibility and acceptability through qualitative and quantitative measures.
  • Efficacy was evaluated using the Clinical Global Impression-Improvement scale and structured diagnostic interviews for remission rates.

Main Results:

  • The adapted therapy demonstrated strong feasibility and acceptability among participants.
  • A 78% treatment response rate (11/14) was observed.
  • A 57% primary diagnosis remission rate (8/14) was achieved at posttreatment.

Conclusions:

  • This adapted exposure therapy/behavioral activation intervention is feasible and acceptable for autistic adolescents with internalizing disorders.
  • Preliminary efficacy data support the intervention's potential, warranting a randomized controlled trial.
  • The findings suggest a promising avenue for improving mental health outcomes in this underserved population.