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Updated: May 19, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
Imaging Sphingosine-1-Phosphate Receptor: A Promising Strategy to Neuroinflammation of Epilepsy
Shuxian Xu1, Yanbo Yu1, Matthew R Brier2
1Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
None:
Epilepsy is a complex neurological disorder characterized by recurrent, unprovoked seizures. Emerging evidence indicates that the sphingosine-1-phosphate receptor (S1PR) family plays a significant and multifaceted role in the pathological processes underlying epileptogenesis and blood-brain barrier integrity. This review comprehensively explores the intricate role of S1PR signaling in epilepsy, with a particular focus on the integration of neuroimaging findings. In this review, we summarize recent advances in Positron Emission Tomography techniques that offer invaluable insights into S1PR-related pathophysiological changes in the epileptic brain. Furthermore, we discuss the substantial potential of S1PRs as novel therapeutic targets. By integrating these cutting-edge neuroimaging biomarkers with our evolving understanding of the underlying molecular pathways, this review aims to highlight promising new diagnostic tools and innovative treatment strategies for epilepsy.
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