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Updated: May 19, 2026

Sperm Collection of Differential Quality Using Density Gradient Centrifugation
Published on: November 29, 2018
Revolutionary Approaches to Sperm Selection: Enhancing Male Fertility Through Advanced Processing Techniques
Rajajeyakumar Manivel1, A S Vickram2, Nidhi Sharma3
1Physiology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha Deemed University, Thandalam, Chennai, Tamil Nadu 602 105 India.
Background:
Male infertility, often worsened by oxidative stress, remains a challenging issue that significantly impacts sperm quality.
Objectives:
Reactive oxygen species (ROS) are key contributors to sperm DNA damage, reduced motility, and abnormal morphology. In response to these challenges, advanced sperm processing techniques like density gradient centrifugation and magnetic-activated sperm cell sorting have been developed to optimize sperm selection and reduce ROS levels.
Conclusion:
This commentary examines recent research on these techniques and their impact on sperm quality, highlighting their potential in the treatment of male infertility.
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