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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Maternal Periodontal Health
1Department of Obstetrics & Gynecology Atal Bihari Vajpayee Institute of Medical Sciences &, Dr Ram Manohar Lohia Hospital, New Delhi, India.
Journal of Obstetrics and Gynaecology of India
|May 18, 2026
Summary
Maternal periodontal disease, a common pregnancy complication, can negatively impact pregnancy outcomes. Early screening and treatment during antenatal care can improve maternal and infant health, though more research is needed.
Area of Science:
- Obstetrics and Gynecology
- Periodontology
- Public Health
Background:
- Periodontal disease is common and often exacerbated during pregnancy due to physiological changes.
- Poor maternal oral health is increasingly linked to adverse pregnancy outcomes but is frequently neglected in antenatal care.
- Hormonal, vascular, and immune shifts during pregnancy heighten susceptibility to periodontal issues.
Purpose of the Study:
- To review the global and Indian prevalence of periodontal disease in pregnancy.
- To elucidate the biological mechanisms linking periodontal disease to adverse perinatal outcomes.
- To evaluate current preventive and therapeutic strategies for managing periodontal disease during pregnancy.
Main Methods:
- A systematic literature search was performed on PubMed, Google Scholar, and Embase for studies from 2015 onwards.
- 44 relevant articles were selected from 206 initially screened based on eligibility criteria.
- Included studies covered epidemiology, pathophysiology, diagnostics, maternal-fetal effects, and treatment outcomes, supplemented by earlier foundational research.
Main Results:
- Pregnancy-related gingivitis is highly prevalent globally; periodontitis rates vary, including in India.
- Periodontal inflammation may trigger systemic inflammation, contributing to preeclampsia, gestational diabetes, preterm birth, low birth weight, and fetal growth restriction.
- Non-surgical periodontal therapy in the second trimester appears safe and may offer a modest reduction in preterm birth and low birth weight, though evidence is mixed.
Conclusions:
- Maternal periodontal disease is a significant, modifiable risk factor affecting pregnancy outcomes.
- Integrating oral health assessments and care into antenatal services can enhance maternal and neonatal health.
- Further rigorous clinical trials are necessary to quantify the benefits of periodontal interventions during pregnancy.
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