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Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...

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Updated: May 19, 2026

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
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Pancreatitis: correcting CFTR expression and function as a promising effective treatment.

Paramita Sarkar1, Wei-Yin Lin1, Ava Movahed Abtahi1

  • 1The Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MA, United States.

Frontiers in Physiology
|May 18, 2026
PubMed
Summary

Impaired function of the cystic fibrosis transmembrane conductance regulator (CFTR) channel is central to pancreatitis. CFTR modulators, used for cystic fibrosis, may offer new pancreatitis treatments.

Keywords:
CFTRcorrectorspancreatitispotentiatorstreatment

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Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
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Area of Science:

  • Gastroenterology and Hepatology
  • Cell Biology
  • Medical Research

Background:

  • The exocrine pancreas relies on acinar cells for enzyme secretion and ductal cells for alkaline fluid and bicarbonate secretion.
  • Ductal secretion, regulated by the cystic fibrosis transmembrane conductance regulator (CFTR) channel, is crucial for pancreatic protection and digestive enzyme transport.
  • Pancreatitis, a prevalent pancreatic disease, is characterized by ductal injury and inflammation, with impaired CFTR function implicated across all forms.

Purpose of the Study:

  • To review evidence linking alterations in CFTR expression and activity to pancreatitis pathogenesis.
  • To explore the potential of CFTR modulators as therapeutic strategies for pancreatitis.

Main Methods:

  • Literature review of studies on CFTR function in pancreatic physiology and pathophysiology.
  • Analysis of existing data on CFTR modulators in cystic fibrosis treatment.

Main Results:

  • Growing evidence implicates dysfunctional CFTR as a common factor in pancreatitis development.
  • CFTR correctors and potentiators are approved and effective for cystic fibrosis treatment.

Conclusions:

  • Altered CFTR expression and activity are key events in the pathogenesis of pancreatitis.
  • CFTR modulators represent a promising therapeutic avenue for pancreatitis, warranting further investigation.