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Microecological modulators-new perspectives for treating sex hormone disorders
Xinhua Li1,2, Xiaoyan Yu2, Yihan Zhong3
1The Second Hospital of Jilin University, Jilin University, Changchun, China.
Frontiers in Microbiology
|May 18, 2026
Summary
The gut microbiota-sex hormone axis influences endocrine health. Probiotics show promise in treating sex hormone disorders by modulating this axis, offering a new therapeutic avenue.
Area of Science:
- Endocrinology
- Microbiology
- Gastroenterology
Background:
- Sex hormone disorders present complex health challenges with limited treatment options.
- Current hormone therapies often cause adverse effects and do not address root causes.
- The gut microbiota-sex hormone axis is crucial for endocrine homeostasis.
Purpose of the Study:
- To review the regulatory mechanisms of the gut microbiota-sex hormone axis.
- To highlight the therapeutic potential of probiotics in sex hormone-related disorders.
Main Methods:
- Systematic review of preclinical and clinical studies.
- Analysis of the role of the gut microbiota in endocrine regulation.
- Evaluation of probiotic interventions targeting the gut microbiota-sex hormone axis.
Main Results:
- Dysregulation of the gut microbiota-sex hormone axis is implicated in sex hormone disorders.
- Probiotics demonstrate efficacy in ameliorating hormonal imbalances and inflammation.
- Specific probiotic strains can optimize metabolic parameters in affected individuals.
Conclusions:
- The gut microbiota-sex hormone axis is a key target for managing sex hormone disorders.
- Probiotics represent a promising adjunctive therapy for these conditions.
- Targeted probiotic interventions offer a novel approach to restore endocrine balance.
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