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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Related Experiment Video

Updated: May 19, 2026

Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
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Dual-Responsive Polyacrylamide Microspheres with Migration Swelling Plugging Time Window for Profile Control in Harsh

Wenwen Yang1, Xiaojuan Lai1, Fanxin Ma2

  • 1College of Chemistry and Chemical Engineering, The Youth Innovation Team of Shaanxi Universities, Shaanxi University of Science & Technology, Xi'an 710021, China.

ACS Omega
|May 18, 2026
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Summary

New dual-responsive polyacrylamide microspheres (PNMA) offer improved water control in challenging oil reservoirs. These smart materials exhibit tunable swelling and shrinking behaviors, enhancing oil recovery in high-temperature and high-salinity conditions.

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Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Published on: September 8, 2016

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Petroleum Engineering

Background:

  • Conventional profile-control agents lack thermal/salt stability and predictable plugging.
  • High-temperature and high-salinity reservoirs pose significant challenges for water management in oil extraction.

Purpose of the Study:

  • To design and synthesize temperature and salinity dual-responsive polyacrylamide microspheres (PNMA).
  • To evaluate PNMA's performance as a water-blocking agent in complex reservoir conditions.

Main Methods:

  • Ternary copolymerization of N-isopropylacrylamide, methacrylic acid, and a quaternary ammonium salt monomer.
  • Characterization of swelling behavior using logistic kinetic and Flory-Rehner models.
  • Evaluation of plugging efficiency through core flooding experiments and adsorption studies.

Main Results:

  • PNMA exhibited tunable swelling (83-573 nm) responsive to temperature and salinity.
  • Amino-ester functionalization enhanced rock-surface adsorption by 40% compared to traditional PAM.
  • Core flooding demonstrated an 82% reduction in high-permeability flow and a 17.5% increase in overall oil recovery.

Conclusions:

  • PNMA microspheres provide a novel solution for water control in harsh reservoir environments.
  • The developed material offers a controllable and effective paradigm for water management and oil stabilization.