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Related Experiment Video

Updated: May 19, 2026

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
09:39

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Published on: April 26, 2018

Spatially Resolved Microglial State Transitions Govern Strain-Specific Zika Neuropathogenesis.

Md Musaddaqul Hasib, Wen Meng, Gonzalo Mena

    Biorxiv : the Preprint Server for Biology
    |May 18, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Zika virus (ZIKV) strains cause distinct brain changes. Asian ZIKV strains promote microglia to contain infection, while African strains lead to inflammation and severe neurological damage.

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    Zika Virus Infection of Cultured Human Fetal Brain Neural Stem Cells for Immunocytochemical Analysis
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    Related Experiment Videos

    Last Updated: May 19, 2026

    Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
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    Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

    Published on: April 26, 2018

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    Zika Virus Infection of Cultured Human Fetal Brain Neural Stem Cells for Immunocytochemical Analysis
    10:27

    Zika Virus Infection of Cultured Human Fetal Brain Neural Stem Cells for Immunocytochemical Analysis

    Published on: February 5, 2018

    Area of Science:

    • Neuroscience
    • Virology
    • Immunology

    Background:

    • Neurotropic viruses disrupt brain homeostasis.
    • Understanding how viral strains affect disease severity and spatiotemporal progression is limited.

    Purpose of the Study:

    • To create a spatiotemporal atlas of Zika virus (ZIKV) infection in the mouse brain.
    • To compare Asian and African ZIKV strains' effects on brain cell populations and tissue architecture.

    Main Methods:

    • Integration of high-resolution spatial transcriptomics with infection-aware cell-type profiling.
    • Analysis of early and late infection stages in mouse models.

    Main Results:

    • ZIKV strains induce structured, strain-dependent reorganization of immune and structural cells, creating infection-associated niches.
    • Asian ZIKV strain infection involves disease-associated microglia (DAM) mediating containment via Apoe-Trem2 signaling.
    • African ZIKV strain infection shows impaired Apoe-Trem2 signaling, persistent inflammation, and failed containment, leading to tissue disruption and neurological deficits.

    Conclusions:

    • A spatially resolved framework links viral strain-specific microglial states to tissue disorganization and neurological impairment.
    • Mechanistic insights into how neurotropic viruses reshape microenvironments driving neurological disease were provided.