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Updated: May 19, 2026

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis

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Published on: March 15, 2016

MolluscaGenes: A Transcriptomic Database for the Mollusca.

Jorge L Pérez-Moreno¹, Paul S Katz¹

¹Department of Biology, University of Massachusetts, Amherst, MA, USA.

Biorxiv : the Preprint Server for Biology

|May 18, 2026

Summary

This summary is machine-generated.

MolluscaGenes is a new database unifying transcriptomes from 299 mollusc species. This resource aids in understanding mollusc evolution and biology, exemplified by a study on nicotinic acetylcholine receptors.

Keywords:

Genomics HMMs chemotactile receptors gene family evolution ion channels nicotinic acetylcholine receptor superfamily protein domains

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Area of Science:

Genomics
Bioinformatics
Evolutionary Biology

Background:

The phylum Mollusca is highly diverse but lacks comprehensive genomic data.
Fragmented transcriptomic resources hinder evolutionary and biological studies in molluscs.

Purpose of the Study:

To create MolluscaGenes, a unified database of molluscan transcriptomes.
To provide tools for enhanced genomic analysis within Mollusca.
To facilitate evolutionary and biological research on molluscs.

Main Methods:

Compiled transcriptomic data from 299 species across all eight mollusc classes.
Developed searchable databases (BLAST, DIAMOND) and molluscan-specific Hidden Markov Models (HMMs).
Conducted a phylum-wide analysis of the nicotinic acetylcholine receptor (nAChR) superfamily.

Main Results:

MolluscaGenes integrates transcriptomes from 299 species, covering diverse tissues and developmental stages.
The nAChR superfamily analysis identified 3,586 sequences across 190+ species, revealing 15 phylogenetic clades.
Discovered lineage-specific expansions, novel nAChR clades with altered ligand-binding residues, and the placement of CRs within the nAChR phylogeny.

Conclusions:

MolluscaGenes is a foundational resource for molluscan research.
The database accelerates the study of unique molluscan biology and evolutionary history.
The nAChR analysis highlights significant evolutionary innovations within Mollusca.