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Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Published on: February 27, 2011

Coordinated Representational Drift Across the Mouse Cortex.

Ryan Peters^1,2,3, James Hope³, Michael Feldkamp³

¹Department of Computer Science, University of Minnesota.

Biorxiv : the Preprint Server for Biology

|May 18, 2026

Summary

This summary is machine-generated.

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Neural representations drift over time, but this change is coordinated across the brain. This coordinated drift maintains spatial map geometry despite individual neuron tuning changes.

Area of Science:

Neuroscience
Systems Neuroscience
Computational Neuroscience

Background:

Cortical neurons exhibit dynamic spatial tuning over days/weeks.
Coordination of this representational drift across cortical networks is poorly understood.

Purpose of the Study:

To investigate how spatial representational drift is coordinated across distributed cortical areas.
To determine if drift is an independent or coordinated process across the dorsal cortex.

Main Methods:

Chronic widefield calcium imaging with cellular resolution in mice over 47 days.
Tracking over 110,000 neurons across retrosplenial, visual, somatosensory, and motor cortices.
Utilizing a robotic cranial exoskeleton for stable imaging during navigation.

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Main Results:

Spatial tuning showed a posterior-to-anterior gradient, with highest tuning in retrosplenial/visual cortices.
Population activity formed a low-dimensional manifold mirroring maze geometry.
All cortical regions decorrelated at similar timescales, with coordinated deviations suggesting synchronized drift.
Drift involved orthogonal transformations preserving spatial representation geometry.

Conclusions:

Representational drift is a coordinated process across the dorsal cortex, not independent.
This coordination maintains the integrity of spatial representations despite continuous neural changes.
The findings reveal principles of large-scale neural coordination in dynamic environments.