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ANYI: The ANnotated Yeast Interactome
Daniel A Nissley1,2, Muskan Goel3, Xavier Castellanos-Girouard4
1National Synthesis Center for Emergence in the Molecular and Cellular Sciences, National Science Foundation, USA.
Biorxiv : the Preprint Server for Biology
|May 18, 2026
Summary
The ANnotated Yeast Interactome (ANYI) database integrates yeast protein-protein interactions with diverse biological features. This resource enables cross-layer analyses of yeast proteome networks and protein properties.
Area of Science:
- * Molecular and Systems Biology
- * Bioinformatics and Computational Biology
Background:
- * Existing protein-protein interaction (PPI) databases lack unified network topology and detailed biological annotations for yeast.
- * There is a need for a comprehensive, protein-centric resource integrating large-scale network data with biophysical and regulatory information.
Purpose of the Study:
- * To develop the ANnotated Yeast Interactome (ANYI), an integrated resource for yeast PPI data.
- * To combine network topology with extensive annotations (e.g., protein abundance, half-life, stability, PTMs) in a unified framework.
- * To facilitate systematic cross-layer analyses of the yeast interactome.
Main Methods:
- * Integrated experimental yeast PPI data with sixteen types of feature annotations.
- * Developed a unified matrix of 3,927 proteins and 155 annotation features.
- * Created an interactive network browser for data visualization and accessibility.
Main Results:
- * ANYI successfully integrates diverse yeast PPI and protein feature data.
- * The resource enables systematic investigation of relationships between network properties and protein characteristics.
- * Users can analyze correlations between protein connectivity and features like stability or disorder.
Conclusions:
- * ANYI provides a valuable, open-access resource for yeast interactome research.
- * The integrated framework facilitates novel discoveries in yeast systems biology.
- * ANYI empowers computational scientists to explore complex protein interaction networks and associated features.
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