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Updated: May 19, 2026

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
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Published on: July 8, 2015

An Operant-based Touchscreen Morph Discrimination Task Does Not Detect Age-related Mnemonic Similarity Deficits in

Aleyna Ross1,2, Carly N Logan1, John J Thompson1

  • 1Evelyn F. McKnight Brain Institute, Center for Cognitive Aging and Memory, Department of Neuroscience, University of Florida, Gainesville, FL 32611, United States.

Biorxiv : the Preprint Server for Biology
|May 18, 2026
PubMed
Summary
This summary is machine-generated.

A new touchscreen task for rats shows sensitivity to stimulus similarity but does not detect age-related memory deficits, unlike older 3D object tasks. This highlights the importance of task design in cognitive aging research.

Keywords:
hippocampusimmediate early genemnemonic similarity taskperirhinal cortexrat

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Animal Models

Background:

  • The Mnemonic Similarity Task (MST) is a sensitive measure of age-related cognitive decline in humans.
  • Rodent adaptations of the MST using 3D objects reveal memory deficits in aged animals.
  • Translational research requires assays that align with human testing and allow for automation.

Purpose of the Study:

  • To develop and validate a touchscreen-based rat analog of the MST using 2D image stimuli.
  • To assess age-related differences in mnemonic discrimination using a morphed Object-Cued Spatial Choice (OCSC) task.
  • To investigate perirhinal cortical activity during mnemonic discrimination in young and aged rats.

Main Methods:

  • Young and aged Fischer 344 × Brown Norway hybrid rats were trained on a touchscreen-based OCSC task with 2D image stimuli.
  • Stimulus similarity was parametrically varied using morphed images to manipulate discrimination difficulty.
  • Perirhinal cortex activity was measured using Arc gene expression following task performance.

Main Results:

  • Both young and aged rats successfully acquired the touchscreen OCSC task.
  • Task performance declined systematically with increasing stimulus similarity, indicating sensitivity to discrimination difficulty.
  • No significant age-related impairment in mnemonic discrimination was observed, contrary to expectations.
  • Arc expression in the perirhinal cortex correlated with behavioral accuracy but did not differ between age groups or overlap conditions.

Conclusions:

  • The touchscreen morph OCSC task is sensitive to stimulus similarity but does not replicate age-related mnemonic discrimination deficits seen in 3D object-based MST paradigms.
  • The findings underscore the critical role of ethological relevance and task design in the translational validity of cognitive assays for aging research.
  • Further research may be needed to optimize rodent models for detecting subtle age-related mnemonic impairments.