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First Successful Regeneration of a Structurally Native-Like Colon Using a Bioabsorbable Polymer Sheet.

Junpei Takashima¹, Mitsuo Miyazawa², Masayasu Aikawa³

¹Department of Surgery Teikyo University School of Medicine, Mizonokuchi Hospital Kawasaki Japan.

Annals of Gastroenterological Surgery

|May 18, 2026

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A novel bioabsorbable polymer sheet (BAPS) effectively closed colonic perforations in pigs. This innovative approach promoted significant colonic tissue regeneration, offering a promising alternative to stoma creation.

Area of Science:

Gastroenterology
Biomaterials Science
Surgical Innovation

Background:

Colonic perforation closure lacks dedicated tools, often necessitating stoma creation.
Investigating bioabsorbable polymer sheets (BAPS) as a less invasive treatment for colonic defects.

Purpose of the Study:

To evaluate the efficacy of BAPS in closing colonic perforations.
To assess the potential of BAPS to induce colonic tissue regeneration.

Main Methods:

A BAPS patch was applied to a 2-cm colonic defect in ten pigs.
Macroscopic and histological evaluations were performed at 4 and 8 weeks post-procedure.
Physiological parameters including blood cell counts and body weight were monitored.

Main Results:

Keywords:

animals bioabsorbable materials colon intestinal perforation tissue regeneration

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Pigs showed no complications, with normalized white blood cell counts and consistent weight gain.
BAPS degraded by 4 weeks, with initial ulcer formation.
By 8 weeks, regenerated mucosa and muscularis mucosae were observed, with reduced defect size (26%).

Conclusions:

BAPS demonstrated successful closure of colonic perforations.
The material facilitated significant regeneration of colonic tissue, resembling native tissue structure.