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Updated: May 19, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

Correction: Emerging insights into chemistry and therapeutic potentials of functionalized hexahydroquinolines

Gbolahan O Oduselu1,2, Rhoda O Olatuyi2, Omowunmi O Fatoki2

  • 1West African Center for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.

Frontiers in Chemistry
|May 18, 2026
PubMed

Keywords:
antiprotozoal agentsdrug discoveryheterocyclic compoundspharmacological potentialquinoline

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Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...