Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the lytic replication...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
DNA Bacteriophages01:26

DNA Bacteriophages

Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects its...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunopathophysiology, biochemistry, and clinical implications of Daboia siamensis venom: A possible challenge to macrophages' immunomodulation.

Asian Pacific journal of allergy and immunology·2026
Same author

<i>Pseudomonas aeruginosa</i> Virulence Bacteriophage Isolated From Inflammatory Mouse Feces Exhibits Bactericidal Activity in Infected Wounds of a Mouse Model.

International journal of microbiology·2026
Same author

Microparticles at the crossroads of the gut-kidney axis: Mechanistic drivers and therapeutic horizons in hemodialysis.

World journal of nephrology·2026
Same author

Corrigendum to: "COVID-19 monitoring with sparse sampling of sewered and non-sewered wastewater in urban and rural communities" [iScience, Volume 26, Issue 7 (2023) 107019].

iScience·2026
Same author

Abdominal Symptoms During the Febrile Phase Indicate Profound Innate Immune Responses in Dengue.

Biology·2026
Same author

Distinct pathophysiological mechanisms of <i>Heterometrus laoticus</i> and <i>Lychas mucronatus</i> scorpion venoms on cardiovascular and renal functions.

The journal of venomous animals and toxins including tropical diseases·2026

Related Experiment Video

Updated: May 19, 2026

T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo
08:46

T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo

Published on: January 26, 2024

Bacteriophages as Immune Modulators: Current Insights and Future Directions.

Kollawat Somsri1,2,3, Nuttawut Sutnu2,3, Sirikan Montathip2,3

  • 1Chulalongkorn University International Medical Program (CU-MEDi), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

PHAGE (New Rochelle, N.Y.)
|May 18, 2026
PubMed
Summary

Bacteriophages, viruses targeting bacteria, offer a promising alternative to antibiotics for treating infections. Research explores their infection cycles, immune modulation, and potential in combating antimicrobial resistance.

Keywords:
anti-inflammationbacteriophagesinflammation modulationinflammatoryphage-therapyphagesphage–host interaction

More Related Videos

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
09:23

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Related Experiment Videos

Last Updated: May 19, 2026

T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo
08:46

T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo

Published on: January 26, 2024

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
09:23

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Area of Science:

  • Microbiology
  • Virology
  • Immunology

Background:

  • Bacteriophages are the most abundant biological entities on Earth.
  • Phage therapy, using bacteriophages to treat bacterial infections, has a long history but declined with antibiotic development.
  • Rising antimicrobial resistance necessitates exploring alternative treatments like phage therapy.

Purpose of the Study:

  • To examine bacteriophage-host cell interactions.
  • To explore bacteriophage infection cycles and their role in personalized phage therapy.
  • To review current research on bacteriophages, including their impact on inflammation and immunity.

Main Methods:

  • Review of existing literature on bacteriophage infection cycles.
  • Analysis of bacteriophage mechanisms in modulating host cell responses.
  • Examination of research on bacteriophage-induced inflammation and immune modulation.

Main Results:

  • Bacteriophages utilize lytic and lysogenic cycles to infect bacteria.
  • Phage therapy is a principal mechanism for treating bacterial infections.
  • Bacteriophages can modulate inflammatory responses and impact host health.

Conclusions:

  • Bacteriophage-based applications are gaining renewed interest due to antimicrobial resistance.
  • Phages show potential as standalone or adjuvant immunological agents.
  • Further research is needed to fully understand and utilize bacteriophages in medicine.