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Related Experiment Video

Updated: May 19, 2026

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
03:53

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 15, 2024

Regenerative peripheral nerve interface following forequarter amputation: a case report.

Jinxian Zhao1, Weichun Liang2, Mingshuang Wang2

  • 1Foshan Hospital of Traditional Chinese Medicine, The Eighth Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.

Frontiers in Surgery
|May 18, 2026
PubMed
Summary
This summary is machine-generated.

Forequarter amputation for cancer can cause severe pain. Regenerative Peripheral Nerve Interface (RPNI) reconstruction during surgery effectively prevented neuroma and phantom limb pain in a patient, improving quality of life.

Area of Science:

  • Oncology
  • Neurosurgery
  • Regenerative Medicine

Background:

  • Forequarter amputation is a radical surgery for shoulder girdle tumors when limb salvage is impossible.
Keywords:
forequarter amputationneuropathic painosteosarcomaphantom limb painregenerative peripheral nerve interface

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The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
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Last Updated: May 19, 2026

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
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Published on: March 15, 2024

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The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

  • Neuroma and phantom limb pain are common, debilitating complications (80-90%) after amputation.
  • Existing nerve management techniques often fail to prevent neuroma recurrence.