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Updated: May 19, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

Triple-negative breast cancer: current understanding and future perspectives

Alhasan Alobaidi1, Vikrant Rai1

  • 1Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.

Exploration of Targeted Anti-Tumor Therapy
|May 18, 2026
PubMed

Insights

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking standard treatment targets. Research highlights its heterogeneity and the need for advanced diagnostics and personalized therapies for better outcomes.

Area of Science:

  • Oncology
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive subtype lacking estrogen receptors, progesterone receptors, and HER2 expression.
  • Standard therapies targeting these receptors are ineffective for TNBC.
  • TNBC disproportionately affects younger women, Black women, and BRCA1 carriers, with high recurrence rates.

Purpose of the Study:

  • To review the current understanding of TNBC biology.
  • To emphasize the need for improved diagnostics and molecular subtyping.
  • To advocate for personalized targeted therapies in TNBC management.

Main Methods:

  • Literature review of TNBC biology, treatment strategies, and challenges.
  • Analysis of current therapeutic approaches including chemotherapy, immunotherapy, ADCs, and PARP inhibitors.
  • Discussion of biological heterogeneity and metastatic potential.

Main Results:

  • TNBC is characterized by rapid growth, early recurrence, and significant biological heterogeneity.
  • Existing treatments like chemotherapy have limitations due to toxicity and resistance.
  • Targeted therapies and immunotherapy show promise but require further development.

Conclusions:

  • TNBC treatment remains challenging due to its complex biology and high metastatic potential.
  • Advanced diagnostics and integrated molecular subtyping are crucial for personalized treatment strategies.
  • Development of novel targeted therapies is essential to improve outcomes for TNBC patients.
Keywords:
immunotherapytherapeutic challengestriple-negative breast cancertumor heterogeneity

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