Lattice Radiation Therapy as a Novel Approach for Renal Cell Carcinoma: A Case Series

Spatially fractionated radiation therapy (SFRT) is a treatment modality initially designed for large, deep-seated tumors. Lattice radiation therapy (LRT), a form of SFRT, delivers high and low doses of radiation (RT) in "peaks" and "valleys," utilizing a three-dimensional pattern while protecting the surrounding organs at risk. We present a case series of two patients with large renal tumors, which were treated with LRT as follows: a 30-year-old male with metastatic renal cell carcinoma (RCC) and a 72-year-old male with RCC and several other comorbidities who completed LRT with minimal toxicity. Both patients received 6670 cGy in 5 fractions delivered twice weekly. These cases support the potential role of LRT in tumor control and symptom palliation. Further research is warranted to delineate the long-term efficacy and toxicity profile of LRT.