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Updated: May 19, 2026

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome
Published on: June 2, 2022
Endothelial-Epithelial Crosstalk Drives Alveolar-Capillary Barrier Dysfunction in ARDS
Juan Shi1, Menglu Qiu1, Siqi Han1
1Department of Pediatrics, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, People's Republic of China.
Abstract:
The alveolar-capillary barrier (ACB) is essential to maintain the function of gas exchange. Acute respiratory distress syndrome (ARDS), is a critical disease characterized by complex etiology and significant clinical heterogeneity. ARDS is pathologically defined by the impairment of ACB integrity, fundamentally driven by maladaptive between alveolar epithelium and pulmonary endothelium that disrupt their coordinated barrier functions. This article systematically reviews the damage mechanism in ARDS, aiming to provide novel theoretical basis and research direction for clinical therapy optimization strategies and prognosis evaluation of ARDS.
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