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Chemerin/ChemerinR1 axis and inflammation-related diseases
Jun Li1,2,3, Changhao Mao1,3,4, Ke Li1,2,3
1School of Clinical Medicine, Chengdu Medical College, Chengdu, China.
Frontiers in Molecular Biosciences
|May 18, 2026
Summary
The Chemerin/ChemerinR1 axis is crucial in inflammation-related diseases, impacting their onset and progression. Targeting this axis offers potential therapeutic strategies and diagnostic biomarkers for conditions like cardiovascular and autoimmune diseases.
Area of Science:
- Biomedical Science
- Molecular Biology
- Immunology
Background:
- Inflammation-related diseases pose significant global health challenges.
- The Chemerin/ChemerinR1 axis, involving an adipokine and its GPCR, regulates inflammation, metabolism, and immune responses.
- Understanding this axis is vital for developing novel therapeutic targets.
Purpose of the Study:
- To review the molecular mechanisms of the Chemerin/ChemerinR1 axis in inflammation.
- To explore the role of this axis in various inflammation-related diseases.
- To highlight its potential as a therapeutic target and diagnostic biomarker.
Main Methods:
- Comprehensive literature review of studies on the Chemerin/ChemerinR1 axis.
- Analysis of signaling pathways activated by Chemerin/ChemerinR1.
- Examination of the axis's involvement in diverse inflammatory conditions.
Main Results:
- The Chemerin/ChemerinR1 axis activates MAPK, PI3K/Akt, and NF-κB pathways, driving inflammation.
- This axis is implicated in hypertension, atherosclerosis, stroke, obesity, rheumatoid arthritis, and inflammatory bowel disease.
- The axis serves as a potential biomarker for early diagnosis and treatment monitoring.
Conclusions:
- The Chemerin/ChemerinR1 axis is a key regulator in inflammation-related diseases.
- Targeting this axis presents a promising therapeutic strategy for vascular and other inflammatory conditions.
- Its role as a biomarker aids in disease management and therapeutic evaluation.
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