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Related Experiment Video

Updated: May 19, 2026

Paper-based Devices for Isolation and Characterization of Extracellular Vesicles
11:53

Paper-based Devices for Isolation and Characterization of Extracellular Vesicles

Published on: April 3, 2015

A novel extracellular vesicle isolation method based on cellulose nanofiber sheets.

Yukari Nagao1, Hiroaki Kajiyama1, Akira Yokoi1,2

  • 1Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Extracellular Vesicles and Circulating Nucleic Acids
|May 18, 2026
PubMed
Summary

Researchers developed a novel cellulose nanofiber-extracellular vesicle (EV) sheet for efficient EV isolation from small sample volumes. This innovation simplifies EV analysis and storage, advancing biomarker discovery and therapeutic applications.

Keywords:
EV sheetExtracellular vesiclebiomarkercellulose nanofiberovarian cancer

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Single Step Isolation of Extracellular Vesicles from Large-Volume Samples with a Bifurcated A4F Microfluidic Device
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Single Step Isolation of Extracellular Vesicles from Large-Volume Samples with a Bifurcated A4F Microfluidic Device

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Last Updated: May 19, 2026

Paper-based Devices for Isolation and Characterization of Extracellular Vesicles
11:53

Paper-based Devices for Isolation and Characterization of Extracellular Vesicles

Published on: April 3, 2015

A Simple Benchtop Filtration Method to Isolate Small Extracellular Vesicles from Human Mesenchymal Stem Cells
09:10

A Simple Benchtop Filtration Method to Isolate Small Extracellular Vesicles from Human Mesenchymal Stem Cells

Published on: June 23, 2022

Single Step Isolation of Extracellular Vesicles from Large-Volume Samples with a Bifurcated A4F Microfluidic Device
06:28

Single Step Isolation of Extracellular Vesicles from Large-Volume Samples with a Bifurcated A4F Microfluidic Device

Published on: February 2, 2024

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Biomedical Sciences

Background:

  • Extracellular vesicles (EVs) are crucial in cell communication and hold potential as disease biomarkers and therapeutic targets.
  • Current EV isolation methods often require large sample volumes, posing limitations for clinical applications.
  • Challenges in methodological transparency and EV subpopulation heterogeneity persist despite increasing clinical trials.

Purpose of the Study:

  • To introduce a novel cellulose nanofiber-EV sheet for efficient EV capture and storage.
  • To address limitations of conventional EV isolation techniques, particularly concerning sample volume.
  • To explore the potential of this new technology for biomarker analysis and research.

Main Methods:

  • Development of a cellulose nanofiber-EV sheet for EV capture from microvolumes (approx. 10 µL) of body fluids.
  • Two application methods: attaching to moist surfaces and soaking into fluids.
  • Utilized the sheet for capture and stable storage of EVs.

Main Results:

  • The cellulose nanofiber-EV sheet enables EV capture and stable storage from small sample volumes.
  • Two distinct application methods (attaching and soaking) offer flexibility.
  • The technology overcomes limitations of conventional methods requiring larger liquid volumes.

Conclusions:

  • The cellulose nanofiber-EV sheet represents a significant advancement in EV isolation technology.
  • This method facilitates biomarker analysis and opens new research avenues.
  • Further development in EV isolation and analytical platforms is crucial for clinical translation.