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Published on: March 3, 2010
An Oxygen Self-Sufficient Nanozyme Engineered From Metal-Organic Cage for Dual-Modal Self-Reporting Theranostics
Shao-Qi Guan1, Zhong-Min Cao1, Wei-Chun Li1
1Department MOE Laboratory of Bioinorganic and Synthetic Chemistry, GBRCE For Functional Molecular Engineering LIFM IGCME, School of Chemistry Sun Yat-Sen University, Guangzhou, China.
Angewandte Chemie (International Ed. in English)
|May 18, 2026
Summary
This study introduces an oxygen-generating nanozyme that enhances photodynamic therapy (PDT) by improving the tumor microenvironment and self-reporting treatment status. The nanozyme offers dual-modal imaging and drug delivery for effective cancer treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Conventional photodynamic therapy (PDT) faces limitations due to the tumor-hypoxic microenvironment.
- Developing intelligent theranostic platforms for self-reporting therapeutic status is crucial.
Purpose of the Study:
- To develop an oxygen self-sufficient nanozyme for enhanced PDT and dual-modal theranostics.
- To create a platform that improves the tumor microenvironment and visualizes therapeutic response.
Main Methods:
- Functionalization of manganese dioxide (MnO2) nanoflowers with supramolecular metal-organic cage (MOC52-L) photosensitizers.
- Integration of catalase-mimetic activity for oxygen generation and therapeutic enzyme activities.
- Loading of lificiguat (YC-1) into MOC52-L for anti-angiogenesis and anti-metastasis.
Main Results:
- The nanozyme efficiently generates oxygen, enhancing type I/II combined PDT.
- Decomposition of MnO2 triggers fluorescence and T1-weighted MRI signal recovery, visualizing tumor accumulation and hypoxia alleviation.
- In vitro and in vivo studies confirmed non-invasive visualization of the treatment zone and excellent anti-tumor performance with high biosafety.
Conclusions:
- The developed nanozyme provides a generalizable strategy for designing activatable theranostic agents.
- This platform enhances imaging-guided PDT and enables turn-on self-reporting of therapeutic initiation.
- The nanozyme demonstrates significant potential for advanced cancer theranostics with improved efficacy and safety.
