Argonaute 2 stabilization of microRNAs controls adult neurogenesis and oligodendrogenesis

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Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
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Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

Xianshuang Liu1, Wanlong Pan1, Michael Chopp1,2

  • 1Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.

Neural Regeneration Research
|May 18, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Argonaute 2microRNAneural stem cellsneurogenesisoligodendrogenesisstabilitystrokesubventricular zone

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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