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Updated: May 19, 2026

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Circular RNAs in tumorigenesis: an insight into recent research in biogenesis and targeted tumor therapy

Zahra Shafaghat1, Pezhman Golshanrad2, Saber Saharkhiz3

  • 1Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Cell Cycle (Georgetown, Tex.)
|May 18, 2026
PubMed

Insights

Circular RNAs (circRNAs) are stable molecules found in eukaryotes. Dysregulated circRNAs in cancer show potential as diagnostic and prognostic biomarkers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are covalently closed eukaryotic RNA molecules.
  • They exhibit high stability and tissue/cell-specific expression patterns.
  • circRNAs are typically expressed at lower levels than their host mRNAs.

Purpose of the Study:

  • To investigate the role of dysregulated circular RNAs in cancer.
  • To explore the potential of circRNAs as cancer biomarkers for diagnosis and prognosis.
  • To understand the involvement of circRNAs in tumor immunity and development.

Main Methods:

  • Analysis of circRNA expression patterns in cancer tissues and sera.
  • Comparison of circRNA levels with mRNA expression.
  • Investigating the correlation between circRNA dysregulation and tumor progression.

Main Results:

  • Circular RNAs are frequently dysregulated in various cancers.
  • Certain circRNAs are detectable in blood and persistent in sera, suggesting biomarker potential.
  • Dysregulated circRNAs impact tumor immunity, indicators, development, and prognosis.

Conclusions:

  • Circular RNAs play significant roles in tumorigenesis.
  • Dysregulated circRNAs offer promising avenues for cancer diagnostics and prognostics.
  • Further research into circRNAs could advance cancer management strategies.
Keywords:
CircRNARNA splicingcancer immunotherapyncRNAtumor microenvironment

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