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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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18F-FDG PET/CT in a Patient With Anal Angiosarcoma.

Xueqi Chen1, Yongchen Zhang2, Caixia Wu1

  • 1Department of Nuclear Medicine, Peking University First Hospital, Beijing.

Clinical Nuclear Medicine
|May 18, 2026
PubMed
Summary

A rapidly growing anal mass in a multiple myeloma patient was diagnosed as angiosarcoma. Positron emission tomography/computed tomography (PET/CT) revealed increased fluorodeoxyglucose (18F-FDG) uptake in the tumor.

Keywords:
PET/CTangiosarcomaanus

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Area of Science:

  • Oncology
  • Pathology
  • Medical Imaging

Background:

  • Multiple myeloma patients undergoing chemotherapy are susceptible to secondary malignancies.
  • Anal masses can present as rapidly growing lesions requiring prompt diagnosis.
  • Angiosarcoma is a rare and aggressive vascular malignancy.

Purpose of the Study:

  • To report a rare case of anal angiosarcoma in a patient with a history of multiple myeloma.
  • To highlight the utility of PET/CT in diagnosing soft tissue malignancies.
  • To discuss the pathological findings of anal angiosarcoma.

Main Methods:

  • Case presentation of a 42-year-old male with a history of multiple myeloma.
  • Positron emission tomography/computed tomography (PET/CT) imaging to evaluate the anal mass.
  • Surgical pathology for definitive diagnosis and characterization of the tumor.

Main Results:

  • A rapidly growing anal mass was identified.
  • PET/CT demonstrated increased 18F-FDG uptake in the anal soft tissue mass.
  • Surgical pathology confirmed a moderately to well-differentiated angiosarcoma of the anus.

Conclusions:

  • Anal angiosarcoma is a rare diagnosis that can occur in patients with a history of multiple myeloma.
  • PET/CT is a valuable tool for detecting and staging soft tissue tumors with high metabolic activity.
  • Early diagnosis and appropriate management are crucial for improving outcomes in angiosarcoma.